Is air trapping really a determinant of persistent airway obstruction in asthmatics?

Relationship between airway obstruction and respiratory symptoms in adult asthmatics.

STUDY OBJECTIVES To characterize the relationship between symptoms and the degree of airway obstruction as determined by the FEV1 and peak expiratory flow (PEF) in a cohort of adult patients attending a university-based urban asthma clinic. DESIGN Each of six current asthma symptoms, including cough, dyspnea, wheeze, chest tightness, sputum production, and nocturnal awakening was rated by pat...

Congenital persistent urachus, urethral obstruction and uroperitoneum in a calf

Persistent patent urachus with other accompanying anomalies like urethral obstruction and uroperitoniumquickly deteriorates animal conditions which necessitate prompt surgical intervention and animal salvage. A10-day-old calf was referred to clinic with mildly distended abdomen, history of umbilical dribbling and nosigns of normal urination since birth. On clinical laboratory results and ancill...

Is a Determinant Judgment Really a Judgment?

Increased airway closure is a determinant of airway hyperresponsiveness.

In order to investigate whether increased airway closure is a component of airway hyperresponsiveness (AHR), airway closure was compared during induced bronchoconstriction in 62 asthmatic, 41 nonasthmatic nonobese (control) and 20 nonasthmatic obese (obese) subjects. Airway closure and airway narrowing were measured by spirometry as percentage change in forced vital capacity (%DeltaFVC) and cha...

Proliferation is not increased in airway myofibroblasts isolated from asthmatics.

Airway mesenchymal cells, such as myofibroblasts and airway smooth muscle cells, contribute to inflammation, airway remodelling and hyperresponsiveness in asthma by excessive proliferation and inflammatory mediator production. Using endobronchial biopsies obtained from both nonasthmatic and asthmatic subjects, in situ proliferation was assessed by immunostaining for cyclin D1. The number of imm...